This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards Guides and Remendations issued by the World Trade Organization Technical Barriers to Trade (TBT)Committee. Designation:F749-20 INTERNATIONAL Standard Practice for Evaluating Material Extracts by Intracutaneous Injection in the Rabbit' This standard is issued under the fixed designation F749;the number immediately following the designation indicates the year of original adoption or in the case of revision the year of last revision.A number in parentheses indicates the year of last reapproval.A superseript epsilon (e)indicates an editorial change since the last revision or reapproval. 1.Scope or other extraction vehicles can be used as described in 1.1 This practice is an intracutaneous reactivity test used to Practice F619.The extract liquid is injected into rabbits and the assess the potential of the material under test to produce animals are observed at regular intervals for 72 h for erythema irritation following intradermal injections of extracts of the edema eschar formation or necrosis. material. 4.Significance and Use 1.2 The liquids injected into the rabbits are those obtained by Practice F619 where the extraction vehicles are saline 4.1 This practice is to be used to help assess the bio- vegetable oil or other liquids simulating human body fluids. patibility...
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